Character: Howard Wolowitz

Constantly teased by Sheldon for being “only an engineer,” Howard Wolowitz also managed to become an astronaut more than halfway into the series. He’s now married to Bernadette, who has always been a bit out of his league. They have two little kids together.

Played By: Simon Helberg

Simon Helberg, who has a decidedly less dorky haircut in real life, is married to actress Jocelyn Towne. Along with Galecki and Parsons, Helberg has gone behind the TV camera to launch other shows.

Character: Amy Farrah Fowler

Amy Farrah Fowler came on The Big Bang Theory as an online date for Sheldon Cooper and became a series regular. She and Sheldon tied the knot in the eleventh season finale. Her neurobiologist character wears dowdy jumpers but has a “wild” streak — or so she thinks.

Played By: Mayim Bialik

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Best known for her starring role in Blossom during the ’90s, Mayim Bialik is a brain in real life — she earned her Ph.D. in neuroscience at UCLA!

She has been outspoken on a number of issues including parenting, depression, modesty in Hollywood and her Jewish faith. She has also published several books, including one about attachment parenting and a vegan cookbook.

Character: Bernadette Rostenkowski-Wolowitz

Bernadette Rostenkowski-Wolowitz may be short and speak with a high-pitched squeak, but she’s also one tough cookie who can bully people into doing her bidding. She just had two children back-to-back, is a successful microbiologist and hasn’t divorced the often-annoying Howard yet — so you know she can handle herself.

Played By: Melissa Rauch

Melissa Rauch’s real-life pregnancy was written into The Big Bang Theory when her character got unexpectedly pregnant with her second child. She’s been open about her own struggles to have a baby and her miscarriage. Rauch also recently wrote and starred in The Bronze, a comedy about an ex-Olympic gymnast.

Character: Stuart Bloom

Comic book shop owner Stuart Bloom is a lovable loser who strikes out with women but has done well in business thanks to a recent Twitter bump from Neil Gaiman. He was living with Howard’s mother as her caregiver for a period of time and is also a regular babysitter for Howard and Bernadette’s kids.

Played By: Kevin Sussman

Also known for his role on Ugly Betty, Kevin Sussman’s role on The Big Bang Theory grew from a recurring character to a series regular.